Treatment of Recalcitrant Generalized Morphea With Infliximab
نویسندگان
چکیده
منابع مشابه
Infliximab in recalcitrant generalized pustular arthropatic psoriasis.
Generalized pustular psoriasis is an unstable inflammatory type of psoriasis, with widespread areas of erythema and sterile pustules, associated with fever and systemic symptoms. Infliximab is a monoclonal antibody with anti-TNFalpha activity, approved for use in psoriasis. We describe a male patient with a long history of stable arthropathic psoriasis, hospitalized with a generalized pustular ...
متن کاملFasciitis associated with generalized morphea.
Figure 1. Photograph of the legs. A large, thickened, firm, hyper/hypopigmented plaque is evident on the left leg. Figure 2. Biopsies of affected skin (A) and contiguous tibialis anterior muscle and fascia from the left leg (B–D). (A) The der-mal collagen is thickened, packed, and hyalinized. The subcutaneous fat is extensively replaced by collagen, and perivascular inflammatory infiltrates are...
متن کاملTwo Cases of Generalized Pustular Psoriasis: Successful Treatment with Infliximab
Vol. 26, No. 6, 2014 787 Received September 12, 2013, Revised January 28, 2014, Accepted for publication February 1, 2014 Corresponding author: Byung-Soo Kim, Department of Dermatology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan 602-739, Korea. Tel: 82-51-240-7338, Fax: 82-51-245-9467, E-mail: [email protected] This is an Open Access article distributed under the terms of...
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Herein we report successful treatment of an adolescent Caucasian female with severe progressive localized scleroderma (mixed subtype, including generalized morphea and linear scleroderma of the trunk/limb) using infliximab and leflunomide. The patient demonstrated improvement after the first 9 months of therapy based on her clinical examination, objective measures, and patient and parent global...
متن کاملSuccessful treatment of recalcitrant palmoplantar pustular psoriasis with sequential use of infliximab and adalimumab.
2nd and 3rd infusions ( fig. 1 e and f). However, treatment with infliximab was discontinued due to an infusion-related reaction with polyarthalgia, myalgia and fever after the 3rd infusion. Although acitretin (30 mg daily) was reintroduced, some painful pustular skin lesions, erythema, fissuring and scaling started reappearing on her feet approximately 8 weeks after the 3rd infusion with infli...
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ژورنال
عنوان ژورنال: Archives of Dermatology
سال: 2010
ISSN: 0003-987X
DOI: 10.1001/archdermatol.2010.120